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  • Chem Sci Trans., 2018, 7(3),  pp 522-530  

    DOI:10.7598/cst2018.1499

    Research Article

    Synthesis, Characterization and In Vitro Antimicrobial Evaluations of Bis-1,4-dihydropyrimidines

  • VARSHA SAMDHIAN1*, SUMEET KAUR BHATIA1, BALBIR KAUR1 and VIKAS MEASHI2
  • 1Department of Chemistry, Punjabi University, Patiala-147002, India
    2Department of Biotechnology, M.M.U. Mullana (Ambala), India
  • Abstract

    Bis-1,4-dihydropyrimidines represents the new class of Biginelli's compounds found with efficient biological properties. The compounds 2(a-k) for the present study were synthesized by alkylation of tetrahydropyrimidines 1(a-k) using 1,6-dibromohexane. All the synthesized compounds were characterized by modern spectral techniques and also screened for antimicrobial activities. The compounds were found to possess moderate to significant bacterial as well as antifungal activities.

    Keywords

    Alkylation, Bis-1,4-dihydropyrimidines, Antimicrobial

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