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  • Chem Sci Trans., 2018, 7(3),  pp 424-444  

    DOI:10.7598/cst2018.1509

    Research Article

    Synthesis, Characterization, In Vitro Anti-diabetic, Antibacterial and Anticorrosive Activity of Some Cr(III) Complexes of Schiff Bases Derived from Isoniazid

  • SATYENDRA N. SHUKLA1*, PRATIKSHA GAUR1, SANGEETA JHARIYA1, BHASKAR CHAURASIA1, PREETI VAIDYA1, DIMPLE DEHARIYA1 and M. AZAM2/sup>
  • 1Coordination Chemistry Research Lab, Department of Chemistry, Govt. Science College, Jabalpur (M.P.), India
    2King Saud University, Riyadh, Saudi Arabia
  • Abstract

    Four complexes of Cr(III) were synthesized with Schiff bases ligands derived from isonicotinyl hydrazide with benzaldehyde/ p-chlorobenzaldehyde. The ligands and complexes were characterized by elemental analysis, molar conductance, magnetic moment, FT-IR, 1H NMR, 13C{1H} NMR and electronic spectroscopy. The molecular structure and different quantum chemical parameters such as dipole moment and polarizability, were calculated using the B3LYP basis set density functional theory (DFT) with the standard 6-311+G(d, 2p) level. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecules. Ligands and complexes were screened for in vitro anti-diabetic and antibacterial activity. Anticorrosion activity of complexes was also studied by weight loss method.

    Keywords

    α-Amylase, Schiff bases, isoniazid, Type II diabetes, Chromium(III) complex

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