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  • Chem Sci Trans., 2018, 7(4),  pp 618-625  

    DOI:10.7598/cst2018.1525

    Research Article

    Synthesis and Biological Evaluation of Urea Derivatives of Combretastatins as Anticancer Agents

  • V. RAMESH1, G. PURNA CHANDER RAO1, B. CHAKRAPANI1 and A. KALYAN CHAKRAVARTHY2*
  • 1Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
    2Dr. Reddy's Laboratories, Integrated Product Development, Bachupally, Hyderabad, India
  • Abstract

    A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity.

    Keywords

    Combretastatin A-4, Sorafenib, Linifanib, Anticancer activity

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