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  • Chem Sci Trans., 2019, 8(1),  pp 109-114  

    DOI:10.7598/cst2019.1535

    Research Article

    Eco-Elegant Approach for the Synthesis, Characterization and Biological Activity of 4-Thiazolidinones

  • PRATEEK PANDEY1, SHRADHA PANDEY2*, and JAGDAMBA SINGH2
  • 1United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India
    2Environmentally Benign Laboratory, Dept. of Chemistry, University of Allahabad, Allahabad, Uttar Pradesh, India
  • Abstract

    Aldimines and 4-thiazolidinones were synthesized by classical method. Aldimines were prepared by heating equimolar mixture of benzaldehyde/substituted benzaldehyde, crude products were monitored by (TLC) thin layer chromatography on silica gel G-plates and recrystallized from ethanol solvent. 4-thiazolidinones IV(a-e) were prepared by aldimines by dissolving in benzene, in the above solution added equimolar amount of thioglycolic acid and heated for about 15-30 minutes. Formation of obtained crude product was checked on TLC and recrystallized from benzene solvent. Compounds IV(a-e) were synthesized through microwave method which led to higher yields with lesser time.

    Keywords

    Conventional, Microwave, Aldimines, 4-Thiazolidinones, Antifungal, Dithane M-45

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