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  • Chem Sci Trans., 2018, 7(4),  pp 588-599  

    DOI:10.7598/cst2018.1539

    Research Article

    Synthesis, Characterisation and In Vitro Biological Evaluation of Novel 3-Chloro-1-(5-ethyl-[1,3,4] thiadiazole-2-yl)-4-phenyl-azetidin-2-one Derivatives

  • SUNIL MAKWANE1*, S. D. SRIVASTAVA1, RAJIV DUA2 and S. K. SRIVASTAVA1
  • 1Synthetic Organic Chemistry Laboratory, Department of Chemistry, School of Chemical Sciences and Technology, Dr. Harisingh Gour University (A Central University), Sagar (M.P), India
    2Department of Chemistry, State Forensic Science Laboratory, Department of Home (Police), Government of Madhya Pradesh, Sagar (M.P), India
  • Abstract

    The 1,3,4-thiadiazole molecules are interesting significance in the field of health pharmaceutics and agriculture. Derivatives of 2-amino-5-ethyl-1,3,4-thiadiazole obtained by cyclization from chloroacetyl chloride in the presence of triethyl amine. Schiff base of 2-amino-5-ethyl-1,3,4-thiadiazole on reaction with aromatic aldehydes afforded compound (1). This compound on further reaction with chloroacetyl chloride in the presence of Et3N yielded 3-chloro-1-(5-ethyl-[1,3,4]thiadiazole-2-yl)-4methyl-azetidin-2-ones (2). Antibacterial and antifungal activities were performed on Bacillus subtilis, Escherichia coli and S tyhpi bacteria and Aspergillus niger, Aspergillus flavus and Fusarium oxisporium fungi respectively. Structures of all the synthesized compounds were confirmed using IR, 1H NMR and 13C NMR and MS spectroscopy.

    Keywords

    Thiadiazole, Azetidine, Antimicrobial and Antifungal

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