Abstract

A simple and convenient method for the synthesis of N3-substituted 3,4-dihydro-pyrimidinones has been achieved by the condensation of 3,4-dihydropyrimidinones with benzoyl chloride in pyridine. The advantages of this method are excellent yields, short reaction time, no-side reaction, operational simplicity and ease in experimental procedure. The key intermediate 3,4-dihydropyrimidin-2(1H)-ones have been synthesized by condensation of β-ketoester, aromatic aldehydes and N-methyl urea using PTSA.

Keywords

Dihydropyrimidinones, PTSA, Benzoyl chloride, Pyridine