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  • Chem Sci Trans., 2018, 7(4),  pp 708-714  

    DOI:10.7598/cst2018.1543

    Research Article

    Convenient Synthesis of Some Novel N3-Substituted 3, 4-Dihydropyrimidin-2(1H)-one Derivatives

  • R. A. SHASTRI
  • P.G. Department of Chemistry, S.B.E.S. College of Science, Aurangabad-431001, Maharashtra, India
  • Abstract

    A simple and convenient method for the synthesis of N3-substituted 3,4-dihydro-pyrimidinones has been achieved by the condensation of 3,4-dihydropyrimidinones with benzoyl chloride in pyridine. The advantages of this method are excellent yields, short reaction time, no-side reaction, operational simplicity and ease in experimental procedure. The key intermediate 3,4-dihydropyrimidin-2(1H)-ones have been synthesized by condensation of β-ketoester, aromatic aldehydes and N-methyl urea using PTSA.

    Keywords

    Dihydropyrimidinones, PTSA, Benzoyl chloride, Pyridine

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