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  • Chem Sci Trans., 2019, 8(3),  pp 368-373  

    DOI:10.7598/cst2019.1591

    Research Article

    Synthesis and Antimicrobial Evaluation of Some Novel 2-(Hydroxyimino)-dihydropyrimidine-5-carboxylic acids

  • R. A. SHASTRI
  • Post Graduate Department of Chemistry, S.B.E.S. College of Science, Aurangabad- 431001 (Maharashtra), India
  • Abstract

    A series of of 1,2,3,4-tetrahydro-2-(hydroxyimino)-6-methyl/1,6-dimethyl-4-phenyl pyrimidine-5-carboxylic acid (2a-o) were prepared by refluxing ethyl-1,2,3,4-tetrahydro-6- methyl/1,6-dimethyl-2-oxo-4-phenylpyrimidine-5-carboxylate (1a-o) with hydroxylamine hydrochloride in the presence of sodium hydroxide, yielded (2a-o) in excellent yields. The advantages of this method is excellent yields, short reaction time, no side reaction and operational simplicity and ease product isolation The structure of all the synthesized compounds were characterized by FT-IR, 1H NMR and MS data. The compounds 2a-o has been screened for their antimicrobial activity. All the compounds possesses significant to moderate antibacterial activity and promising antifungal activity.

    Keywords

    Dihydropyrimidinones, Hydroxylamine hydrochloride, Sodium hydroxide

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