• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2019, 8(4),  pp 534-548  

    DOI:10.7598/cst2019.1596

    Research Article

    Electrochemical Behavior of Antidepressant Drug Vilazodone Hydrocholoride and its Determination at F-MWCNT-Nafion/GCE Sensor

  • MAHADEVA SINGH JAT, KALPANA, K. K. JHANKAL and D. K. SHARMA*
  • Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur (Rajasthan)-302004, India
  • Abstract

    A sensitive electroanalytical method for determination of vilazodone hydrocholoride in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode. Vilazodone gave one well-defined oxidation peak at 0.721 potential versus Ag/AgCl reference electrode in citrate buffer of pH 6.5. Oxidation process was irreversible and diffusion controlled. Diffusion coefficients (2.32x10-4 cm2/s and 6.45x10-4cm2/s), surface coverage (4.23x1033mol/cm2 and 98.01x10-3 mol/cm2) and heterogeneous rate constant (0.767s-1 and 1.241s-1) were calculated at both bare GCE and f-MWCNT-nafion modified GCE respectively. Increase values of said parameters proved that f-MWCNT-nafion, doped on bare GCE, positively catalyzed electron transfer between electrode-electrolyte interfaces. Based on CV, CPC and pH studies a oxidation mechanism was proposed involving 2H+/2e-. The proposed square wave voltammetric method shows linearity over the concentration range (0.2x10-5-3.6x10-4M). The achieved limits of detection (LOD) and quantification (LOQ) are 9.6x10-8 g/mL and 3.23x10-7 g/mL respectively. The proposed method was successfully employed for the assay of drug in bulk formulations, human blood and human urine samples.

    Keywords

    Vilazodone hydrochloride, Antidepressant, Cyclic voltammetry, Glassy carbon electrode, Square wave voltammetry

    This article has been viwed 402 times

      

    Citations for this article 0

      

    No Citations