Abstract

Condensed quinazolines like thiadiazolo quinazolines and corresponding bioisostere thiadiazolo thienopyrimidines were found to be biologically active molecules. An attempt was made to utilize the concept of bio-isosterism for the synthesis of 3-amino2- mercapto5, 6, 7, 8-tetrahydro-benzo (b)thieno-(2,3-d)-pyrimidine-4-(3H)-ones which was further treated with acetylchloride, urea, carbondisuiphide, chloroacetic acid, benzoin to affords novel fused thiadiazole, thiadiazine compounds. The novel synthesized compounds were characterized by MP, IR, ¹H NMR spectra. These synthesized compounds were subjected to anti-microbial studies using few gram-positive, gram-negative and fungal organisms. The standard drug used for anti-microbial activity was ampicillin and ketoconazole respectively and also tested for their anti-cancer activity by MTT assay method. The tested compounds exhibited significant antimicrobial and anti-cancer activity.

Keywords

Benzothienopyrimidines, Thiadiazoles, Thiadiazines, Anti-microbial activity, Anti- cancer activity