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  • Chem Sci Trans., 2012, 1(2),  pp 431-439  

    DOI:10.7598/cst2012.184

    Research Article

    Synthesis and Characterizaton of Some N-Mannich Bases as Potential Antimicrobial, Anthelmintic and Insecticidal Agents

  • RITA BAMNELA and S. P. SHRIVASTAVA*
  • Department of Chemistry, Govt. Postgraduate College, Damoh-470661, Madhya Pradesh, India
    *Heterocyclic Research Laboratory, Department of Chemistry, Dr. Hari Singh Gour Central University, Sagar-470 003, Madhya Pradesh, India
  • Abstract

    A series of N-Mannich bases of benzimidazolyl substituted 1H-isoindole-1,3(2H) dione have been derived by the reaction of different substituted amino acids with phthalic anhydride to yield 2-(substituted) 1H-isoindole-1,3(2H) diones (3), further condensation with o-phenylenediamine yields 2-substituted benzimidazolyl 1H-isoindole-1,3(2H) diones (4), followed mannich reaction with methanal and different amines to yields final products (5). The chemical structures of synthesized N-Mannich bases were determined by elemental analysis and spectral data (FTIR & 1H NMR). All the synthesized derivatives have been evaluated for their antimicrobial, anthelmintic and insecticidal activities against microbes, helminthes and insects selected as compared to standard drugs by using disc diffusion method and Watkins technique respectively. All the synthesized N-Mannich bases possess the significant antimicrobial, anthelmintic and insecticidal activities.

    Keywords

    Mannich base, 1H-isoindole-1, 3(2H)-dione, Antimicrobial, Anthelmintic, Insecticidal activities

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