• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2012, 1(2),  pp 317-320  

    DOI:10.7598/cst2012.199

    Research Article

    A Simple Spectrophotometric Estimation of Tramadol Hydrochloride in Pharmaceutical Formulations

  • K. NAGARAJA SETTY*, T. RAMACHARa, I. E. CHAKRAVARTHYb and K. PRABHAVATHIc
  • *Department of Chemistry, Government Degree College for Men, Kurnool-518002, India
    aDepartment of Chemistry, G. Pulla Reddy Engineering College, Kurnool-518002, India
    b Department of Chemistry, Rayalaseema University, Kurnool-518002, A.P, India
    cDepartment of Chemistry, S. B. S.Y. M. Degree College, Kurnool-518004, A.P, India
  • Abstract

    A simple, accurate, rapid and sensitive spectrophotometric method has been developed for the determination of tramadol hydrochloride in pharmaceutical formulations. The method was based on the formation of chloroform extractable complex of tramadol hydrochloride with wool fast blue, which shows absorbance maxima at 590 nm against the reagent blank treated similarly. The method obeys Beer's law in the concentration ranges of 50-250 g/mL. Validation studies are statistically significant as all the statistical parameters are within the acceptance range (% RSD< 2.0 and S.D. < 2.0) for both accuracy and precision study. High recovery and low % RSD reveals the reliability of the method for quantitative study of the proposed method in tablet formulation. The proposed method is simple, rapid accurate, precise, reproducible and economic and can be used for routine quantitative analysis of tramadol hydrochloride in pure and tablet dosage form.

    Keywords

    Ultraviolet-visible spectrophotometry, Tramadol hydrochloride, Wool fast Blue, (WFB), Formulations

    This article has been viwed 4006 times

      

    Citations for this article 13

      

    Download Citations