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  • Chem Sci Trans., 2012, 1(3),  pp 494-499  

    DOI:10.7598/cst2012.214

    Research Article

    Uncatalyzed Synthesis of Heteroarylidine Derivatives in Aqueous Medium and their Antibacterial Evaluation

  • PRADEEP K. PALIWAL, SRINIVASA RAO JETTI and SHUBHA JAIN*
  • Laboratory of Heterocycles, School of Studies in Chemistry & Biochemistry, Vikram University, Ujjain-456010, Madhya Pradesh, India
  • Abstract

    Knoevengal condensation of heteroaryl aldehydes with active methylene compounds in aqueous medium at room temperature is described. The products are obtained with excellent yields in short reaction times without using any catalyst. Products require no further purification. Newly synthesized compounds have shown good to excellent biological activities against Staphylcoccus aureus, Klebsialla pneumoniae, Escherichia coli and Pseudomonas aeruginosa.

    Keywords

    Knoevenagel condensation, Aqueous media, Antibacterial activity, Heteroarylidine

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