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  • Chem Sci Trans., 2012, 1(2),  pp 335-340  

    DOI:10.7598/cst2012.219

    Research Article

    Synthesis and Crystal Structure Analysis of Ethyl-4-(4-acetoxy-phenyl)-3-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate

  • HONNAPPA NAGARAJAIAH and NOOR SHAHINA BEGUM*
  • Department of Chemistry, Bangalore University, Bangalore-560001, India
  • Abstract

    4-(4-Acetoxy-phenyl)-3-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (2) was synthesized by a two step reaction process. Preliminary spectroscopic analysis was done by IR, 1HNMR and elemental analysis. The crystal and molecular structure was further confirmed using single crystal x-ray diffraction. The dihedral angle between the planes of the aryl and dihydropyrimidine rings is 89.65(6), which is almost orthogonal. The dihydropyrimidine ring adopts twist-boat conformation. The crystal structure is stabilized by C-HO, N-HS and C-Hp interactions.

    Keywords

    Dihydropyrimidine, crystal structure, C-HO, N-HS and C-Hp weak interactions.

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