Abstract

Bio-inspired gold nanoparticles are rapidly synthesized at room temperature using grapes fruit extract. A green and low cost synthesis is effective in the formation of stable crystalline gold nanoparticles in the solution. Polyphenols which is present in the grapes fruit extract function as reducing as well as stabilizing agent to produce shape controlled gold nanoparticles. Surface plasmon resonance confirmed the formation of gold nanoparticles in UV-Visible spectra at 500 nm. The Fourier transform infrared spectroscopy (FTIR) analysis was carried out to identify and study the functional groups responsible for the bio-reduction of gold ion. High resolution transmission electron microscopy (HRTEM) images showed the spherical crystalline gold nanoparticles. Thermogravimetric analysis (TGA) measures the weight loss of gold nanoparticles as a function of temperature under a controlled atmosphere. The synthesized gold nanoparticles showed excellent antimicrobial activity towards most of the tested fungal and bacterial culture. It showed good anticancer activity against HeLa cell lines.

Keywords

Gold nanoparticles, Grapes, Polyphenols, Antimicrobial activity, Cytotoxicity