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  • Chem Sci Trans., 2012, 1(3),  pp 716-722  

    DOI:10.7598/cst2012.223

    Research Article

    Synthesis and Antimicrobial Activity of Some Novel Chalcones of 3-Acetyl Pyridine and their Pyrimidine Derivatives

  • M.V.JYOTHIa*, Y. RAJENDRA PRASADb, P. VENKATESHc and M. SURESHREDDYa
  • aDepartment of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, K.R.Palli Cross, Anantapur-515 721, (A.P), India
    bUniversity College of Pharmaceutical Sciences, Andhra University,
    Visakhapatnam-530 003, (A.P), India
    cNational Institute of Pharmaceutical Education and Research, Balanagar,
    Hyderabad - 500037 (A.P), India
  • Abstract

    Chalcones afford a facile route of access to many of the heterocyclic systems containing oxygen and nitrogen. An attempt is therefore made to synthesize chalcones from 3-acetylpyridine by reaction with either aromatic or heteroaromatic aldehyde using Claisen-Schmidt condensation. The resulting chalcones after purification and characterization by physical and spectral methods have been successfully converted into substituted pyrimidines by reaction with guanidine hydrochloride. All these compounds were characterized by means of their IR, 1H NMR, 13C NMR and mass spectral data. These compounds were evaluated for antimicrobial activities by cup plate method.

    Keywords

    Chalcones, Synthesis, Antimicrobial activity

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