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  • Chem Sci Trans., 2012, 1(3),  pp 688-696  

    DOI:10.7598/cst2012.243

    Research Article

    Novel Piperazinyl-Quinazoline-4-one Analogs: Design, Synthesis and Evaluation of In Vitro Biological Activity

  • K. N. MYANGAR*, T. N. AKHAJA, D. R. NAIK and J. P. RAVAL
  • Department of Pharmaceutical Chemistry, Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), ADIT Campus, New Vallabh Vidhyanagar 388 121, Dist: Anand, Gujarat, India
  • Abstract

    A series of novel 2-[4-substituted-piperazinyl-methyl]-3-[N-isonicotinamide-yl]-quinazoline-4-one (4a-l) were designed, synthesized, characterized and evaluated for in vitro antitubercular, antibacterial and antifungal activity. Compounds 4f, 4h and 4l exhibited excellent antitubercular activity against mycobacterium tuberculosis H37Rv.

    Keywords

    Piperazine, 2-Chloromethyl-3-(N-isonicotinamide-yl)-4Hquinazolinone, Antitubercular activity

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