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  • Chem Sci Trans., 2013, 2(1),  pp 19-24  

    DOI:10.7598/cst2013.244

    Research Article

    Effects of Shaddock (Citrus maxima) Fruit Juice on Glucose Tolerance and Lipid Profile in Type-II Diabetic Rats

  • A. OYEDEPOT and S.O. BABARINDE
  • Department of Biological Sciences, Adeleke University, Ede P.M.B. 250, Ede, Osun State, Nigeria
  • Abstract

    Cirus maxima commonly known as Shaddock has been proved for hypoglycaemic effects. The objective of the present study was to evaluate the effects of Shaddock (C.maxima) fruit juice on glucose tolerance and lipid profile in streptozotocin (STZ) induced type-II diabetic rat. Two days old neonatal pups (710 g) were used and they were made diabetic by intraperitoneally (i.p.) injection of 90 mg/kg STZ in citrate buffer solution. Different groups of animals were treated by 25% and 50% Shaddock fruit juice (SFJ) for 8 weeks. After 8 weeks treatment biochemical parameters from blood serum were analyzed. The significant differences of glucose, cholesterol, HDL, LDL, triglyceride, in 50% SFJ treated group compare to diabetic group were found. Therefore we conclude from this present study that Shaddock fruit juice has beneficial effects on glucose tolerance and lipid profile in streptozotocin-induced type-II diabetic rat.

    Keywords

    Shaddock fruit juice (SFJ), Diabetes mellitus, Blood Glucose, Cholesterol, Lipid parameters

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