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  • Chem Sci Trans., 2012, 1(3),  pp 632-637  

    DOI:10.7598/cst2012.274

    Research Article

    Synthesis and Biological Activity of Some Novel Phenyl Pyrazoline Derivatives

  • SHAILESH H SHAH* and PANKAJ S PATEL
  • *Department of Chemistry, Patel JBR Arts, Patel AMR Commerce & Patel JDKD Science College, Borsad & JJT-University, Rajasthan, India
    Department of Chemistry, Sheth LH Science College, Mansa, India
  • Abstract

    A new series of 4-(4-hydroxyphenyl)-3-chloro-1-{4-[5-(substituted phenyl)-1-phenyl- 4,5-dihydro-pyrazol-3-yl]phenyl}azetidin-2-one were synthesized by reacting 3-chloro-1-{4-[3-(substituted-phenyl)prop-2-enoyl]phenyl}-4-(4-hydroxyphenyl)azetidin-2-one (0.01 M) and phenyl hydrazine (0.01 M) in presence of acetic acid (glacial). All these compounds were characterized by means of their IR, 1H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.

    Keywords

    Chalcones, Phenyl pyrazolines, Azetidin-2-one, Antimicrobial activity

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