A simple spectrophotometric method has been developed for the estimation of valacyclovir in pharmaceutical preparations. The method is based on the reaction of the valacyclovir with methanolic solution of para dimethyl amino benzaldehyde (PDAB) in acidic condition producing Schiff base having absorption maximum at 400 nm. Beer’s law is obeyed in the concentration of 50-250 µg/mL of valacyclovir. Statistical analysis proves that the proposed method is reproducible and selective for the estimation of valacyclovir in bulk drug and in its tablet dosage form.
Spctrophotometry, Valacyclovir, para dimethyl amino benzaldehyde, Formulations