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  • Chem Sci Trans., 2013, 2(4),  pp 1089-1093  

    DOI:10.7598/cst2013.301

    Research Article

    Design, Synthesis and Pharmacological Evaluation of New Series of Pyrazolines Based Thiazolidin-4-one Derivatives

  • PINKA PATEL, DEEPA GOR and P. S. PATEL
  • K. K Shah Jarodwala Maninagar Science College, Ahmedabad-8, India
    Department of Chemistry, Sheth L. H. Science College, Mansa-382845, India
  • Abstract

    We have prepared 2-{4-[2-{5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}-3-(substituted phenyl)-1,3-thiazolidin-4-one form N-[{4-[2-{5-(4-chloro-phenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}methylene] substituted aniline and thioglycolic acid. Compound having an excellent properties regarding as per as anti cancer and HIV as compared to this compound. Physical properties of pure crystallized substance of 2-{4-[2-{5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-yl}-2-oxoethoxy]phenyl}-3-(subs-tituted-phenyl)-1,3-thiazolidin-4-one substituted aniline like M.P elementary analysis and spectral data of compound and such as IR and NMR will be evaluated and confirm the structure of compound. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.

    Keywords

    Synthesis, Pyrazoline, Chalcones, Schiff base, DMSO, Antimicrobial activity

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