A series of 10 new 1,3-thiazolidin-4-one (3a-3j) were synthesized from different schiff base of N-[(1E)-(3-chloro-5,7-dimethyl-2-naphthyl) methylene]aniline (2a-2j) with thioaceticacid. The chemical structures of these compounds were confirmed by means of 1H NMR, IR and mass analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of bacterial strains such Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and fungi strain Aspergillus niger at 40 µg/mL. The resulted of compounds shows that chloro and flouro substituted 1,3-thiazolidine-4-one derivatives are showing quite well activity as compare to the other functional groups.
1,3-Thiazolidin-4-one, 2-Chloro-6, 8-dimethyl quinoline-3-carboxaldehyde, Schiff base, Antimicrobial evaluation