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  • Chem Sci Trans., 2013, 2(1),  pp 176-180  

    DOI:10.7598/cst2013.315

    Research Article

    Rapid and Efficient Synthesis of 2,3-Dihydro-1H-1,5-Benzodiazepines Catalyzed by Chloroacetic Acid Screened among Various Aliphatic Acids under Solvent Free Conditions

  • AKSHDEEP SANDHAR and RAJESH K. SINGH
  • Pharmaceutical Chemistry Division, Shivalik College of Pharmacy (Under Local Govt Deptt., Punjab) Nangal, Distt.Rupnagar, Punjab-140126, India
  • Abstract

    A series of 1, 5-benzodiazepines were synthesized by condensation of o-phenylenediamine with different ketones and effect of different aliphatic acids used as catalyst was studied. Among the various acids screened, chloroacetic acid came out to be a versatile catalyst and the corresponding products were obtained in good to excellent isolated yields (85-94%) under solvent free conditions.

    Keywords

    1, 5-Benzodiazepines, o-Phenylenediamine, Ketones, Aliphatic acids, Chloroacetic acid, Solvent free conditions

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