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  • Chem Sci Trans., 2013, 2(1),  pp 113-122  

    DOI:10.7598/cst2013.331

    Research Article

    Synthesis and In Vitro Antioxidant Evaluation of Some Indole-2-carboxylic Acid-Aryl Amine Conjugates

  • NAGARAJA NAIK, V. SHARATH, H. VIJAY KUMAR and H. SWETHA
  • Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
    Department of Organic Chemistry, Indian Institute of Science, Banglore-570012, Karnataka, India
    Plantation Products, Spices & Flavour Technology, Central Food Technological and Research Institute, Mysore-570006, Karnataka, India
  • Abstract

    A simple and efficient protocol for the synthesis of novel indole-2-carboxylic acid analogues having aryl amine moieties (2a-k) has been described. The synthesized compounds were characterized by spectroscopic techniques (IR, 1H NMR, 13C NMR and MS-EI) and further screened for their antioxidant activity by using various in vitro assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS+) radical scavenging activity, ferric reducing antioxidant power, cupric ion reducing ability method and phosphomolybdate method. In all the antioxidant assays performed, compounds 2b, 2d, 2e and 2f showed promising antioxidant activity. Whereas, compound 2c displayed potent antioxidant activity.

    Keywords

    Free radicals, Antioxidant activity, Indole-2-carboxylic acid, Aryl amines

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