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  • Chem Sci Trans., 2013, 2(1),  pp 123-128  

    DOI:10.7598/cst2013.334

    Research Article

    Synthesis and Anticonvulsant Activity (Chemo Shock) of Phenothiazine Amino Acid Derivatives

  • PANDEYA SURENDRA NATH, YADAV MEENA K and TRIPATHI LAXMI
  • Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Ahimamau, Sultanpur Road, Lucknow-226002(U.P) India
    S.D.College of Pharmacy and Vocational Studiesdepartment of Pharmacy, Muzaffar Nagar, U.P. 251001, India
  • Abstract

    Amino acid derivatives of phenothiazine scaffold were synthesized and screened for their anticonvulsants activity against chemo shock induced screening to study the mechanism of action of anticonvulsants. Strychnine, thiosemicarbazide and 4-aminopyridine were used for induction of seizures. Rotorod test was used to study the neurotoxicity profile of these compounds. All these compounds protected against strychnine and thiosemicarbazide (20 mg/kg) induced seizures at a dose of 30 mg/kg up to 2 h. In case of 4-aminopyridine (13.3 mg/kg) induced seizure, protection was observed only up to 15 minute which was followed by death of the animals.

    Keywords

    Phenothiazine, Amino acids, Strychnine, Thiosemicarbazide, 4-Aminopyridine, Anticonvulsants

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