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  • Chem Sci Trans., 2013, 2(2),  pp 379-384  

    DOI:10.7598/cst2013.335

    Research Article

    Synthesis, Characterization, Antibacterial, Antifungal and Anticancer Studies of a New Antimetabolite:
    N-[(Diphenylamino)methyl]acetamide and Some of Its Inner Transition Metal Chelates

  • L. MURUGANANDAM, K. KRISHNA KUMAR and K. BALASUBRAMANIAN
  • Department of Chemistry, Saranathan College of Engineering, Tiruchirapalli-12, India
    Department of Chemistry, National Institute of Technology, Tiruchirapalli-15, India
  • Abstract

    N-[(Diphenylamino)methyl]acetamide was synthesized using Mannich reaction and its complexes of cerium(IV), thorium(IV) and dioxouranium(VI) were prepared and characterized by elemental analysis and various spectral studies. The bidendate chelation of ligand, bonding through carbonyl oxygen and azomethine nitrogen is suggested. Based on spectral and magnetic studies, hexa coordinate geometry is assigned for all the complexes. The complexes were screened for their antibacterial, antifungal and anticancer activities. They show positive results.

    Keywords

    Physicochemical, Tuberculosis, Monosubstituted, Antimetabolite, Lipophilic

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