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  • Chem Sci Trans., 2013, 2(1),  pp 251-257  

    DOI:10.7598/cst2013.337

    Research Article

    Analytical Method Development for Determination of Performance of Adapalene in Adapalene 0.1% Gel Formulation Using Manual Diffusion Cell

  • S.S.DEO, F. INAM and N. P. KARMARKAR
  • Department of Chemistry, Institute of Science, Rabindranath Tagore Road, Civil Lines, Nagpur-440010, India
  • Abstract

    A simple, reliable and reproducible method applicable for topical creams is developed to monitor the in vitro performance of adapalene 0.1% cream formulations using manual diffusion cell with suitable synthetic membrane and receptor medium. The membranes which have permeability similar to skin and receptor media that can maintain the sink conditions have been selected. For solid oral dosage forms such as tablets, extensive study and analytical methods were developed to evaluate the in vitro performance of the drug. But for semisolid dosage forms, no official guideline exists to measure its performance. Therefore, to quantify the performance of the adapalene 0.1% cream, in vitro release method is developed with manual diffusion cell and analysed using high performance liquid chromatography.

    Keywords

    In vitro release, Manual diffusion cell, Synthetic support membranes, Receptor medium, Reverse phase-high performance liquid chromatography

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