Different benzaldehydes and pyridine substitution were used on 1 and 4 ‘N’-positions of thiosemicarbazide respectively. This substituted-benzaldehyde-2-aminopyridine-N-thiohydrazone ligand was further used to synthesize Co(II), Ni(II) and Co(II) based metal complexes and characterized by FT-IR, Elemental analysis, ESI Mass and elemental analysis. All synthesized compounds were studied for their physical properties, antibacterial and antifungal activity. In this anti-microbial study Cu(II) and Ni(II) metal complexes have shown better anti-bacterial activity. While several synthesized metal complexes have shown comparable activity with standard drugs taken.
Thiosemicarbazones, Complexes, Antimicrobial activity, Synthesis