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  • Chem Sci Trans., 2013, 2(1),  pp 135-140  

    DOI:10.7598/cst2013.349

    Research Article

    Synthesis and Characterization of Cu(II), Ni(II) and Co(II) Based 1,
    4-Substituted Thosemicarbazone Complexes

  • RAKESH M. TADA, TUSHAR S. MAHETA, MITESH B. GONDALIYA and MANISH K. SHAH
  • Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Abstract

    Different benzaldehydes and pyridine substitution were used on 1 and 4 N-positions of thiosemicarbazide respectively. This substituted-benzaldehyde-2-aminopyridine-N-thiohydrazone ligand was further used to synthesize Co(II), Ni(II) and Co(II) based metal complexes and characterized by FT-IR, Elemental analysis, ESI Mass and elemental analysis. All synthesized compounds were studied for their physical properties, antibacterial and antifungal activity. In this anti-microbial study Cu(II) and Ni(II) metal complexes have shown better anti-bacterial activity. While several synthesized metal complexes have shown comparable activity with standard drugs taken.

    Keywords

    Thiosemicarbazones, Complexes, Antimicrobial activity, Synthesis

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