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  • Chem Sci Trans., 2013, 2(2),  pp 423-428  

    DOI:10.7598/cst2013.374

    Research Article

    Synthesis and Biological Activities of 3-Alkyl-5-substituted 1,2,4-Triazole Derivatives

  • N. U. SIDDIQUI, MOHD. ASLAM and RAJESH KUMAR
  • Department of Chemistry, G.F. (P.G.) College, Shahjahanpur (U.P.)-242001, India
  • Abstract

    Starting from the ester (methyl/ethyl) with hydrazine hydrate, a variety of new compounds 3-alkyl-5-(3’5’dimethyl-1-H-pyrazole-1!-yl)-1,2,4,-triazole (5a & 5b); 3-alkyl-5-(N-pyrazolidine)-amino-1,2,4-triazole (6a & 6b) and 2-alkyl-4-mercapto (1,2,4)-triazole (3,4-b) 1,3,4-triazole (7a & 7b) have been synthesized. All proposed structures were supported by IR, 1H-NMR, 13C NMR and elemental analysis. These newly synthesized compounds (5a & 5b-7a & 7b) have been screened for their antibacterial activity on E. coli, P. aeruginosa, S. aureus and
    S. pyrogenes
    and antifungal activity on C. albicans, A. niger and A. clavatus.

    Keywords

    Alkyl-substituted-1,2,4-triazoles, Antimicrobial activity, Synthesis

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