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  • Chem Sci Trans., 2014, 3(1),  pp 281-291  

    DOI:10.7598/cst2014.378

    Research Article

    Synthesis, Characterizationand Antibacterial Activity of Quaternary Ammonium Compounds Bearing Mixed N-Substituted Groups

  • SOFIANE DAOUDI, ADIL A. OTHMAN, TAHAR BENAISSA and ZAHRA OULD KADA
  • Laboratory of Bioactive Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology of Oran -Mohamed Boudiaf, P.O.Box 1505 El-M’naouer, Oran 31003, Algeria
  • Abstract

    Sixteen quaternary ammonium bromides [QAB]4(a-d)-7(a-d)bearing mixed N-branches were synthesized by treating n-butyl 2a, cyclohexyl 2b, 2,3,4,6-tetra-O-acetyl – D- glucosyl 2c and cholesteryl 2d bromides, separately with n-butyl amine 3a, benzyl amine 3b, N,N-dimethyl amino ethyl-2- methyl acrylate 3c and
    N,N-diethyl amino ethyl-2- methyl acrylate 3d. N,N-Diphenyl amine 3e failed to react with any bromides within the scope of this work. The synthesized bromides and QAB were characterized by FT-IR, 1H NMR and 13C NMR. All compounds were tested for their activity against some gram-positive and gram-negative bacteria and some of them exhibited significant antibacterial activities.

    Keywords

    Alkyl and cycloalkyl bromides, Benzyl bromides, Dialkylaminomethyl acrylate bromides, Quaternary ammonium compounds, Antibacterial activity

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