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  • Chem Sci Trans., 2013, 2(2),  pp 656-662  

    DOI:10.7598/cst2013.379

    Research Article

    New RP-UFLC Method for Estimation of Xanthinol Nicotinate in Pharmaceutical Dosage Form

  • SAGAR SUMAN PANDA, B.V.V. RAVI KUMAR, PINKAL KUMAR PATEL and
    JNYANARANJAN PANDA
  • Department of Pharmaceutical Analysis and Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India
  • Abstract

    A novel, accurate and precise RP-UFLC method for determination of xanthinol nicotinate has been developed and validated. Separation was achieved on an Enable C18G column (250 mm 4.6 mm i.d., 5 m) using acetonitrile: 10 mM TBAHS (40:60, v/v) as mobile phase at a flow rate of 0.8 mL/min and PDA detection at 274 nm. Linearity was observed in the concentration range of 1.0-60 g/mL (r2=0.999). The method was validated for accuracy, precision, stability, specificity, robustness and system suitability. Forced degradation was performed by using HCl, NaOH, H2O2, thermal and UV radiation. The method was used successfully for the determination of xanthinol nicotinate in tablet dosage form.

    Keywords

    Xanthinol, RP-UFLC, Validation, Stability, Nicotinic acid

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