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  • Chem Sci Trans., 2013, 2(2),  pp 663-669  

    DOI:10.7598/cst2013.402

    Research Article

    Inclusion Complex of Thiourea Substrate with Hydroxypropyl--cyclodextrin

  • AHMAD ALLOUCH, INAS EL HASSAN, ADIB ABOU DALLE, HANNA El-NAKAT and
    FAWAZ EL OMAR
  • Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University,
    P.O. Box 826, Tripoli, Lebanon
    Department of Chemistry, Faculty of Science, University of Balamand, P.O. Box 100, Tripoli, Lebanon
  • Abstract

    To be active, a heavy metal trap substrate must possess some degree of aqueous solubility. The use of cyclodextrins molecules, which can form inclusion complexes with the hydrophobic trap substrates, has provided the required solubility through the relatively hydrophobic cavity of native cyclodextrins and their derivatives that enhances the ability to complex hydrophobic substrates of appropriate size and shape. In this study, spectrophotometry has been used to investigate the effects of cyclodextrin on the solubility, stoichiometry and stability of the substrate-CD complex formed between N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, (a hydrophobic substrate trap) and hydroxypropyl--cyclodextrin (HP??CD). The solubility, stoichiometry and overall association constant of the complex have been determined using the Higuchi's method, the continuous variation (Job's plot) method and the Scott's method respectively.

    Keywords

    Thiourea, Inclusion complexes, Cyclodextrin

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