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  • Chem Sci Trans., 2013, 2(2),  pp 684-690  

    DOI:10.7598/cst2013.432

    Research Article

    Spectrophotometric Methods for the Assay of Ceftazidime in Bulk and its Pharmaceutical Formulations

  • L. MOHAN KRISHNA, P. JAYACHANDRA REDDY, V. JAYA SANKAR REDDY and
    K.V. S. PRASADA RAO
  • Krishna Teja Pharmacy College, Tirupati, India
    Rahul Institute of Pharmaceutical Sciences, Chirla, India
  • Abstract

    Three visible spectrophotometric methods have been described for the assay of ceftazidime (CTZ) either in bulk form or dosage forms. Methods A-C are based on the oxidation of CTZ with an excess of oxidant (N-bromosuccinimide (NBS) in methods A and B or chloramine-T (CAT) in method C) in acidic medium. The unreacted oxidant was then estimated colorimetrically by using an oxidisable dye (Celistine blue (CB) in method A or gallocyanine (GC) in method C) or by p-N-methyl aminophenol sulphate (PMAP)- sulphanilamide (SA) reagent in method B. Regression analysis of Beers law plots showed good concentration range 2.0-10.0 g/mL, 4.0-16.0 g/mL and 1.0-8.0 g/mL for methods A, B and C respectively and gives reproducible results.

    Keywords

    Spectrophotometry, NBS, Ceftazidime , Gallocyanine

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