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  • Chem Sci Trans., 2013, 2(3),  pp 859-864  

    DOI:10.7598/cst2013.440

    Research Article

    Design and Biological Evaluation of 2,2'-Dinitrodiphenylmethane Derivatives

  • A. JEPA MALAR*, M. CHRISTUDHAS and G. ALLEN GNANA RAJ
  • Department of Chemistry, N. M. Christian College, Marthandam, Tamilnadu-629165, India
    Department of Chemistry, Scott Christian College (Autonomous), Nagercoil, Tamilnadu-629003, India
  • Abstract

    Synthesis of 4,4',5,5'-tetrabromo-2,2'-dinitrodiphenylmethane and 5,5'-dibromo-2,2'-dinitrodiphenylmethane from 4,4'-diamino-5,5'-dibromo-2,2'-dinitrodiphenylmethane are reported. 4,4',5,5'-Tetrabromo-2,2'-dinitrodiphenylmethane (TBNDPM) have been synthesized by a simple and convenient method employing Sandmeyer’s reaction of 4,4'-diamino-5,5'-dibromo-2,2'-dinitrodiphenylmethane (ABNDPM) with cuprous bromide and hydrobromic acid and 5,5'-dibromo-2,2'-dinitrodiphenylmethane (BNDPM) has obtained by treatment of ABNDPM with hypophosphorous acid and cuprous oxide. The structures of the synthesized compounds are assigned on the basis of elemental and spectral analysis (UV-visible, FTIR and 1H-NMR). The synthesized compounds have been evaluated for the antibacterial and antifungal efficacy.

    Keywords

    Sandmeyer’s reaction, Cuprous bromide, Hydrobromic acid, Hypophosphorous acid, Antimicrobial activity

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