Synthesis of 4,4',5,5'-tetrabromo-2,2'-dinitrodiphenylmethane and 5,5'-dibromo-2,2'-dinitrodiphenylmethane from 4,4'-diamino-5,5'-dibromo-2,2'-dinitrodiphenylmethane are reported. 4,4',5,5'-Tetrabromo-2,2'-dinitrodiphenylmethane (TBNDPM) have been synthesized by a simple and convenient method employing Sandmeyer’s reaction of 4,4'-diamino-5,5'-dibromo-2,2'-dinitrodiphenylmethane (ABNDPM) with cuprous bromide and hydrobromic acid and 5,5'-dibromo-2,2'-dinitrodiphenylmethane (BNDPM) has obtained by treatment of ABNDPM with hypophosphorous acid and cuprous oxide. The structures of the synthesized compounds are assigned on the basis of elemental and spectral analysis (UV-visible, FTIR and 1H-NMR). The synthesized compounds have been evaluated for the antibacterial and antifungal efficacy.
Sandmeyer’s reaction, Cuprous bromide, Hydrobromic acid, Hypophosphorous acid, Antimicrobial activity