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  • Chem Sci Trans., 2013, 2(S1),  pp S95-S98  

    DOI:10.7598/cst2013.442

    Research Article

    Organophosphorus Insecticides Induced Alterations in Liver of Male Albino Rat

  • KHALID H. GATHWAN, ISAM HUSSAIN T. AL-KARKHI and ABEER KHALID YASEEN
  • Collage of Dentistry/University of Baghdad. Bab Almozam, Baghdad, Iraq
  • Abstract

    Pesticides cause ecological problems which may leads to immediate mass mortality in addition to biological magnifications. Liver plays very important role in mammalian metabolism. Liver is the primary site for any toxic substance and suffered first. The present study revealed the toxic effect of organophosphorus in albino rat through plasma and liver enzymes. Adult male rats 70 days old, weighing 150-170 g were treated orally with of monocrotophos (1/5 LD50, 3.5 mg/kg bw) and methyl parathion (1/5 LD50, 4.8 mg/kg bw) for 60 days. The liver weight, aminotransferase, acid phosphatase and alkaline phosphatase in homogenates and plasma were estimated. It was found that the levels of acid phosphatase, alkaline phosphatase, aspartate aminotransferases and alanine aminotransferases were significantly (p<0.05) increased in liver with all of two organophosphates. It has been concluded that (monocrotophos and methyl parathion) caused increasing in the levels of phosphatase and aminotransferase as well as decreased in liver weight.

    Keywords

    Liver, Mice, Aminotransferase, Organophosphorus

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