Investigation of Various Green Chemistry Approaches for the Efficient Synthesis of Dialkyl-1, 4-dihydro-4-(substituted phenyl)-2, 6-dimethylpyridine-3, 5-dicarboxylate

Chem Sci Trans., 2013, 2(S1), pp S295-S301

DOI:10.7598/cst2013.443

Research Article

Investigation of Various Green Chemistry Approaches for the Efficient Synthesis of Dialkyl-1, 4-dihydro-4-(substituted phenyl)-2, 6-dimethylpyridine-3, 5-dicarboxylate

Abstract

A green chemistry methodologies were utilized for the efficient synthesis of Hantzsch 1,4-dihydropyridine derivatives by one-pot multicomponent reaction of substituted aldehydes, ethyl/methyl acetoacetate and ammonium acetate by conventional, microwave, solvent-free and ultrasonication techniques. All the compounds were characterized by TLC, FT-IR, ¹H NMR and elemental studies.