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  • Chem Sci Trans., 2013, 2(4),  pp 1110-1117  

    DOI:10.7598/cst2013.449

    Research Article

    Indirect Spectrophotometric Determination of Cephalexin in Pharmaceutical Formulations

  • REBWAR O. HASSAN
  • Department of Chemistry, College of Science, University of Salahaddin, Erbil, Iraq
  • Abstract

    Simple, reliable and sensitive indirect spectrophotometric method was developed for the determination of cephalexin in pharmaceutical products without pretreatment. The method was based on the fading effect of the cephalexin on developed color product resulted from the bromination reaction of NBS with
    p-anisidine in acidic medium, subsequently vanished colored species was measured at 522 nm. Cephalexin acts in accordance with the Beer’s law, under optimum conditions, at concentration ranges 1.5-10.0 μg/mL
    (R = 0.9949) with detection limit of 0.90 μg/mL. The relative standard deviation and error percent for 3 replicate determinations were found to be 2.2% and 1.75%, respectively. The proposed method was applied to the determination of cephalexin in different pharmaceutical products. A comparison of the method reported is made with standard official method and can be used as a convenient analysis method for routine quality control.

    Keywords

    Indirect spectrophotometric, Cephalexin, Pharmaceutical products

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