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  • Chem Sci Trans., 2013, 2(3),  pp 883-888  

    DOI:10.7598/cst2013.457

    Research Article

    Synthesis and Antimicrobial Screening of Some Novel 2-(2-Chloroquinolin-3-yl)-3-(1-phenylamine)-1,3- thiazolidin-4-ones

  • R. A. SHASTRI
  • P. G. Department of Chemistry, Milind College of Science, Aurangabad 431002, India
  • Abstract

    2-Chloro-3-formylquinoline derivative (1) on treatment with phenyl hydrazine (2) yields Schiff’s bases 2-(2-chloroquinolin-3-yl)methylene-2-phenyl hydrazine (3a-e). Compound 3a-e on treatment with thioglycollic acid and catalytic quantity of ZnCl2 in methanol yields the title compounds 4a-e. The newly synthesized compounds 4a-e have been screened for their antibacterial and antifungal activities and their chemical structures have been elucidated by IR, NMR spectral data. Some of them exhibited significant antifungal activity.

    Keywords

    2-Chloro-3-formylquionline, Thioglycolic acid, 1,3-Thiazolidin-4-one

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