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  • Chem Sci Trans., 2013, 2(S1),  pp S234-S238  

    DOI:10.7598/cst2013.466

    Research Article

    Potentiometric Determination of Pharmaceutically Important Nimesulide in Non-Aqueous Medium

  • VAISHALI R. PATIL and PRADIP P. DEOHATE
  • Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444001, India
  • Abstract

    The method of potentiometric determination of pharmaceutically important nimesulide by using isopropyl alcohol as the solvent and alcoholic KOH as the titrant has been developed. The titrations were carried out using glass and calomel electrodes. Study of the effect of solvent, concentration and the estimation of nimesulide in single component tablets has been also carried out. The method was found to be satisfactory for assay of nimesulide and results obtained are comparable with those obtained by British Pharmacopoeia (B. P) method.

    Keywords

    Nimesulide, Potentiometric determination, Non-aqueous medium

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