An efficient and economically feasible microwave-assisted eco-friendly reaction was developed for the preparation of β-amino alcohols from aminolysis of epoxides. The reaction was executed on the reusable perchloric acid supported silica matrix (HClO4–SiO2) surface in a microwave. The yields of β-amino alcohols are uniformly good. The applicability of the catalyst was studied in the synthesis of propranolol, a cardiovascular drug. The results were presented.
Microwave irradiation, Epoxides, Reusable catalyst, Silica perchloric acid, Propranolol