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  • Chem Sci Trans., 2013, 2(3),  pp 805-812  

    DOI:10.7598/cst2013.471

    Research Article

    Silica Perchloric Acid Matrix Supported Ring Opening of Epoxide Under Microwave Radiation†

  • Y. L. N. MURTHY*, BHAGAVATHULA S. DIWAKAR, B. GOVINDH, R. VENU and K. NAGALAKSHMI
  • Organic Research Labs, Dept. of Organic Chemistry, Andhra University, Visakhapatnam-530 003, India
    Department of Materials Science and Engineering, Chungnam National University, South Korea-305 764, India
  • Abstract

    An efficient and economically feasible microwave-assisted eco-friendly reaction was developed for the preparation of β-amino alcohols from aminolysis of epoxides. The reaction was executed on the reusable perchloric acid supported silica matrix (HClO4–SiO2) surface in a microwave. The yields of β-amino alcohols are uniformly good. The applicability of the catalyst was studied in the synthesis of propranolol, a cardiovascular drug. The results were presented.

    Keywords

    Microwave irradiation, Epoxides, Reusable catalyst, Silica perchloric acid, Propranolol

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