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  • Chem Sci Trans., 2013, 2(3),  pp 964-968  

    DOI:10.7598/cst2013.477

    Research Article

    Synthesis, Characterization and Antimicrobial Study of Substituted Benzopyranone Derivatives

  • MOHSEN A M GOMAA
  • Science College, Chemistry Division, King Faisal University, Al-Hufuf-31982, Saudi Arabia Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt
  • Abstract

    Reaction of 6-formylbenzopyranone derivative (1) with 2-(1-phenyl-ethylylidene) malononitrile led to formation of 7-hydroxy-chromen-6-yl-(1-phenyl-allylidene) malononitrile (2). Reaction of 2 with hydrazines led to formation of the corresponding aminopyrazole derivatives 3 and 4. While reaction of 2 with thiourea led to formation of 4,6-diaminopyrimidin-2-thione derivative 5. Hydrolysis of 2 with ammonium hydroxide afforded 2-cyano-5-(7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-yl)-3-phenyl-penta-2,4-dienoic acidamide (6). The structures of the new compounds were confirmed on the basis of the elemental analysis and spectral data. All the synthesized products were evaluated for their antimicrobial activity.

    Keywords

    Chromones, Benzopyrane, Pyrazole, Pyrimidinthione, Biological activity

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