Abstract

Reaction of 6-formylbenzopyranone derivative (1) with 2-(1-phenyl-ethylylidene) malononitrile led to formation of 7-hydroxy-chromen-6-yl-(1-phenyl-allylidene) malononitrile (2). Reaction of 2 with hydrazines led to formation of the corresponding aminopyrazole derivatives 3 and 4. While reaction of 2 with thiourea led to formation of 4,6-diaminopyrimidin-2-thione derivative 5. Hydrolysis of 2 with ammonium hydroxide afforded 2-cyano-5-(7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-yl)-3-phenyl-penta-2,4-dienoic acidamide (6). The structures of the new compounds were confirmed on the basis of the elemental analysis and spectral data. All the synthesized products were evaluated for their antimicrobial activity.

Keywords

Chromones, Benzopyrane, Pyrazole, Pyrimidinthione, Biological activity