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  • Chem Sci Trans., 2013, 2(3),  pp 1063-1069  

    DOI:10.7598/cst2013.527

    Research Article

    Synthesis, Characterization and Biological Activities of a New 5-Chloroisatin Schiff Base and its Metal Complexes

  • RAGHAVENDRA RAO*, K RAMAKRISHNA REDDY and K. N. MAHENDRA
  • Department of Chemistry, Central College Campus, Bangalore University, Bangalore - 560 001, India
    Government Science College, Bangalore - 560 001, India
  • Abstract

    Copper(II), cobalt(II), nickel(II) and zinc(II) complexes of 5-chloroisatin Schiff base (L) (L= Schiff base derived from 5-chloroisatin and 2-methyl-4- nitro aniline) were synthesized and characterized. The authenticity of the ligand and its metal complexes had been established by micro analysis, IR, NMR, LC/MS, UV-Vis and electrical conductance measurements. The ligand acts as a bidentate in which the carbonyl oxygen and the azomethine nitrogen of 5-chloroisatin are involved in co-ordination. Square planar geometry was proposed for Cu(II) and Ni(II) complexes and tetrahedral geometry was proposed for Co(II) and Zn(II) complexes. The ligand and its metal complexes have been screened for their antibacterial activity against bacterias viz. Staphylococcus aureus and Escherichia coli etc. and antifungal activity against fungi Aspergillus niger and Aspergillus flavous etc. The activities of both the samples have shown significant and noticeable changes on complexations.

    Keywords

    Schiff base, Isatin, Antibacterial activity, Antifungal activity

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