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  • Chem Sci Trans., 2013, 2(4),  pp 1304-1311  

    DOI:10.7598/cst2013.542

    Research Article

    Benign by Design Synthesis of Novel 1H-Tetrazoles: Spectral Characterization and Antibacterial Activities

  • G. SHANMUGAM, D. BHAKIARAJ, S. ELAVARASAN, T. ELAVARASAN and M. GOPALAKRISHNAN
  • Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar - 608002, Tamilnadu, India
  • Abstract

    New tetrazole analogues with bio-active cores have been synthesized by a novel synthetic methodology. The synthesized compounds were characterized using FT-IR, MS, elemental analysis, 1H, 13C and HSQC NMR spectroscopic techniques. The synthesized compounds were screened for their antibacterial activities against Staphylococcus aureus, Escherichia coli, Vibreo cholerae, Pseudomonas aeruginosa and Klebsiella pneumonia. The synthesized compounds are showing very good activities against all the tested bacterial strains.

    Keywords

    11H-tetrazole, HSQC analysis, Antibacterial activity

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