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  • Chem Sci Trans., 2014, 3(2),  pp 486-493  

    DOI:10.7598/cst2014.548

    Research Article

    Synthesis, Characterization and Anti Microbial Activity of Some Novel Heterocyclic Compounds Having Sulphamido Moiety

  • RAMBABU NUNNA, D. RAMACHANDRAN, VIRAL B. MODI and KIRTI J.GOSWAMI
  • Department of Chemistry, Shri U. P. Arts, Smt. M. G. Panchal Science & Shri V. L. Shah Commerce College, Pilvai, India
    2Acharya Nagarjuna University, P. G. Centre, Nuzvid, Andhrapradesh, India
  • Abstract

    4-Amino-N-[4-(4-chloro-phenyl)-6-(3,4-dimethyl-phenyl)-pyrimidin-2-yl]-benzensulfonamide (2) was prepared by the hydrolysis of N-{4-[4-Chloro-phenyl}-6-(3,4-dimethyl-phenyl)-pyrimidin-2-ylsulfamoyl]-phenyl}-acetamide (1). It was on-facile condensation reaction with various aromatic aldehydes yields Schiff bases /anils/azomethines (3a-h). These anils on reaction with maleic anhydride and succinic anhydride yield 2H-pyrrole-2-ones (4a-h) and 2-pyrrolidinones (5a-h) respectively. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

    Keywords

    2H-Pyrrole-2-ones, 2-Pyrrolidinones, Facile condensation, Schiff base, Antimicrobial activity

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