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  • Chem Sci Trans., 2014, 3(1),  pp 11-18  

    DOI:10.7598/cst2014.549

    Research Article

    Piperidine Mediated Synthesis of Hetero Chalcones and 8-Substituted-2, 5-dihydro-2-(2-furanyl)-4-(2-thienyl)-1, 5-benzothiazepines as Antibacterial Agents

  • N. BHASKER, Y. PRASHANTHI and B V. SUBBA REDDY
  • Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India
    Guru Nanak Institute and Technical Campus, (JNTU) Hyderabad, A.P, India
  • Abstract

    The reactions of 5-substituted-2-amino benzenethiols with hetero chalcones 3 have been carried out in dry toluene containing catalytic amount of piperidine, the products, 8-substituted-2,5-dihydro-2-(2-furanyl)-4-(2-thienyl)-1,5-benzo thiazepines 5 and hetero chalcones 3 were synthesized by piperidine mediated condensation of an ethanolic solution of a 1-thiophen-2-yl-ethanone 2 with corresponding furan-2-carbaldehyde 1. The structures have been established on the basis of elemental (C, H, N) analysis, IR, 1H NMR, Mass spectral data. The compounds 3 and 5 were screened for antimicrobial activities against a variety of bacterial agent

    Keywords

    8-Substituted-2, 5-Dihydro-2-(2-furanyl)-4-(2-thienyl)-1, 5-Benzothiaze pines, Hetero chalcones, Antibacterial activity

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