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  • Chem Sci Trans., 2013, 2(4),  pp 1443-1449  

    DOI:10.7598/cst2013.553

    Research Article

    A Catalyst Free Synthesis and In Vitro Antimicrobial Studies of a Series of Bis-Schiff Bases

  • MOHAMMED ZAMIR AHMED, SHAIKH K A, ASGAR JAFAR KHAN FIRDOUS G. KHAN, ASRAR AHMED KHAN and SHAIKH KHALED
  • Organic Chemistry Research Laboratory, Yeshwant Mahavidyalaya, Nanded-431602 (MS), India
    P.G Department of Chemistry, Sir Sayyad College of Arts, Commerce and Science, Aurangabad- 431001 (MS), India
    Laboratory of Organic Synthesis, Milliya College, Beed- 43112 (MS), India
    School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded- 431606 (MS), India
    School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded- 431606 (MS), India
  • Abstract

    A series of bis-Schiff bases (3a-l) has been synthesized by condensation of substituted hydrazones (1a-l) with 3,5-dibromosalicylaldehyde (2) at room temperature within a short period of time under catalytic free conditions. The chemical structures of the synthesized compounds were confirmed on the basis of spectral analysis data. The bis-Schiff base derivatives (3a-l) were further screened for their in vitro antibacterial activity against plant, human pathogenic bacteria (Erwinia carotovora, Xanthomonas citri, Proteus vulgaris, Staphylococcus aureus) and antifungal (Alternaria and Curvularia lunata) studies. Compounds (3a-l) showed promising activities against S. aureus and Proteus vulgaris.

    Keywords

    Hydrazones, Dibromosalicylaldehyde, Bis-Schiff bases, Antimicrobial activity

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