A series of bis-Schiff bases (3a-l) has been synthesized by condensation of substituted hydrazones (1a-l) with 3,5-dibromosalicylaldehyde (2) at room temperature within a short period of time under catalytic free conditions. The chemical structures of the synthesized compounds were confirmed on the basis of spectral analysis data. The bis-Schiff base derivatives (3a-l) were further screened for their in vitro antibacterial activity against plant, human pathogenic bacteria (Erwinia carotovora, Xanthomonas citri, Proteus vulgaris, Staphylococcus aureus) and antifungal (Alternaria and Curvularia lunata) studies. Compounds (3a-l) showed promising activities against S. aureus and Proteus vulgaris.
Hydrazones, Dibromosalicylaldehyde, Bis-Schiff bases, Antimicrobial activity