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  • Chem Sci Trans., 2013, 2(4),  pp 1475-1481  

    DOI:10.7598/cst2013.560

    Research Article

    Spectrophotometric and Thermodynamic Studies of the Inclusion Complexation of Thiourea Substrate with Hydroxypropyl-β-cyclodextrin

  • INAS EL HASSAN, AHMAD ALLOUCH, ADIB ABOU DALLE, HANNA El-NAKAT and FAWAZ EL OMAR
  • Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University,
    P.O. Box 826, Tripoli, Lebanon
    Department of Chemistry, Faculty of Science, University of Balamand, P.O. Box 100, Tripoli, Lebanon
  • Abstract

    A simple and fast spectrophotometric method has been used to determine the thermodynamic parameters of the inclusion complex formed between N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, a hydrophobic substrate trap and hydroxypropyl-β-cyclodextrin (HP?β-CD). The overall association constants have been calculated at different temperatures using the Scott's method and are found to decrease with increase in temperature. The free energy change (ΔG) and the enthalpy of formation (ΔH) as well as the entropy (ΔS) have been determined for the various inclusions. The method has been applied with satisfactory precision; the values of relative standard deviations did not exceed 2%.

    Keywords

    Thiourea, Inclusion complex, Cyclodextrin, Association constant

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