Abstract

New, rapid and accurate spectrophotometric procedure was developed, to determine the 6-(trifluoro methyl)furo[2, 3-b]pyridine-2-carbohydrazide analogues in pure form. The method was based on the reaction of these analogues as n-electron donors with the sigma-acceptor iodine. The obtained charge transfer complexes were measured at 370 nm for iodine in water. The obtained complexes were examined by using the UV, IR and ¹H NMR spectral analysis. A complete detailed investigation of the formed complex was made with respect to the association constant and free energy change. The association constants were calculated using iodine method and Rose-Dragoequation. The values of association constants show a strong donor-acceptor interactions, which help to study the possible site of interaction between the donors and the acceptors.

Keywords

Spectrophotometry, Charge transfer complexes, Fluoro-pyrine-2-carbohydrazides, Iodine