• image 01
    Volume 1, No.1, 2012
  • image 02
    Volume 1, No.2, 2012
  • image 01
    Volume 1, No.3, 2012
  • image 02
    Volume 2, No.1, 2013
  • image 02
    Volume 2, No.2, 2013
  • image 02
    Volume 2, No.S1, 2013
  • image 02
    Volume 2, No.3, 2013
  • image 02
    Volume 2, No.4, 2013
  • image 02
    Volume 3, No.1, 2014
  • image 02
    Volume 3, No.2, 2014
  • Volume 3, No3
    Volume 3, No.3, 2014
  • Volume 3, No4
    Volume 3, No.4, 2014
  • Volume 4, No1
    Volume 4, No.1, 2015
  • Volume 4, No2
    Volume 4, No.2, 2015
  • Volume 4, No3
    Volume 4, No.3, 2015
  • Volume 4, No4
    Volume 4, No.4, 2015
  • Volume 5, No1
    Volume 5, No.1, 2016
  • image 01
  • image 02
  • Login|Register
  • Chem Sci Trans., 2013, 2(4),  pp 1482-1490  

    DOI:10.7598/cst2013.608

    Research Article

    Cytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands

  • WAEL HUSSEIN HEGAZY and MANAL HASSAN MARZOUK
  • Department of Chemistry, Faculty of Science, Suez University, Suez, 43533, Egypt
    Clinical Biochemistry and Molecular Biology Unit, Cancer Biology Department, National Cancer Institute,
    Cairo University, Cairo, 11553, Egypt
  • Abstract

    In this paper, we report the synthesis, characterization and antitumor studies of Co(II), Ni(II) and Cu(II) complexes with two potentially hexadentate ligands. Antitumor activity of the prepared ligands and its complexes against human breast cancer cell line MCF-7 was determined. The level of total protein, nucleic acids (RNA and DNA) and nitric oxide (NO) in MCF-7 treated cells was estimated. Antitumor activities of the complexes are accompanied with over-production of free and superoxide radicals allowed reactive oxygen species-mediated tumor cell death. The results show significant antitumor activity comparable to cisplatin

    Keywords

    MCF-7, Nucleic acids, Antitumor activities, Transition metal complexes, Hexadentate hydrazonic ligands, Cytotoxicity

    This article has been viwed 2448 times

      

    Citations for this article 0

      

    No Citations