Abstract

The aim of this study was to investigate the effect on antioxidant enzymes and malondialdehyde (MDA) in rat serum and various tissues of chronic diazepam application. Rats were exposed to diazepam intraperitonally twice a day for six weeks. The change in enzyme activity levels was determined. Diazepam was given in 1 mg/kg doses. In liver tissue, catalase (CAT) activity showed a significant decrease when diazepam group was compared to the control group (p <0.05). Superoxide dismutase (SOD) activity showed a significant increase in kidney tissue of diazepam group. GPx activity decreased in all tissues when diazepam group was compared to the control group. Although, changes in the level of MDA was not statistically significant in groups. These data indicate that chronic diazepam administration may cause to moderate oxidative stress conditions.

Keywords

Diazepam, Catalase activity, Malondialdehyde, Superoxide dismutase, Metabolism in rats