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  • Chem Sci Trans., 2014, 3(1),  pp 303-313  

    DOI:10.7598/cst2014.641

    Research Article

    Synthesis, Spectral Studies and Antibacterial Activities of 8-Hydroxyquinoline Derivative and its Metal Complexes

  • S. S. SYED ABUTHAHIR A. JAMAL ABDUL NASSER, S. RAJENDRAN and G. BRINDHA
  • PG & Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli-620 020, India
    Department of Chemistry, RVS School of Engineering and Technology, Dindigul-624 005, India
  • Abstract

    1-(8-Hydroxy quinolin-2yl-methyl) thiourea ligand (HTF) was synthesized from 8-hydroxyquinoline and thiourea with formaldehyde by condensation method in N,N-dimethyl foramide medium. The metal complexes Zn(II), Cu(II), Ni(II) and Co(II) were prepared using the 1-(8-hydroxy quinolin-2yl-methyl) thiourea as ligand. The ligand and its metal complexes were characterized by elemental analysis, FT-IR, UV-Visible, cyclic voltammetry, Mass spectra and NMR spectroscopy. The ligand and its metal complexes possess antibacterial activity for certain bacteria such as Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa and C.tropicalis.

    Keywords

    8-Hydroxyquinoline derivative, Antibacterial screening, Thiourea derivative, Cyclic Voltammetry

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